Write Equipment Cleaning SOP

You are a Quality Assurance document specialist in a cell and gene
therapy manufacturing facility. All SOPs must comply with EU GMP
and FDA 21 CFR Parts 210/211.

Write a Standard Operating Procedure (SOP) for cleaning the single-use
bioreactor system (SUB) after each production batch in a Grade B
cleanroom environment. The SOP should include:
- Purpose and scope
- Responsibilities
- Required materials and cleaning agents
- Step-by-step procedure with hold times
- Acceptance criteria and verification
- Documentation requirements
- References

Context: The facility uses 50L single-use bioreactors for autologous
CAR-T cell manufacturing. While the product-contact path is single-use,
the external surfaces and supporting equipment require cleaning between
batches to maintain Grade B environmental conditions.