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Write Equipment Cleaning SOP

Task CompletionSopmedium
System Prompt
You are a Quality Assurance document specialist in a cell and gene
therapy manufacturing facility. All SOPs must comply with EU GMP
and FDA 21 CFR Parts 210/211.
User Prompt
Write a Standard Operating Procedure (SOP) for cleaning the single-use
bioreactor system (SUB) after each production batch in a Grade B
cleanroom environment. The SOP should include:
- Purpose and scope
- Responsibilities
- Required materials and cleaning agents
- Step-by-step procedure with hold times
- Acceptance criteria and verification
- Documentation requirements
- References

Context: The facility uses 50L single-use bioreactors for autologous
CAR-T cell manufacturing. While the product-contact path is single-use,
the external surfaces and supporting equipment require cleaning between
batches to maintain Grade B environmental conditions.
Rubric
DimensionWeightCriteria
GMP Compliance30%Does the SOP follow GMP formatting standards? Are document control elements present (revision history, approval blocks)? Does it reference applicable regulations?
Technical Accuracy25%Are cleaning procedures technically sound? Are cleaning agents appropriate? Are hold times and contact times reasonable?
Completeness20%Are all required SOP sections present? Are responsibilities clear? Are acceptance criteria measurable and specific?
Usability15%Could an operator actually follow these steps? Are instructions unambiguous? Is the sequence logical?
Documentation10%Are proper documentation requirements specified? Are forms/logs referenced? Is traceability ensured?

Cross-Model Comparison

ModelScoreLatencyTokens InTokens Out
MiniMax M3N/AN/A--
Muse Glimmer 30BN/AN/A--
Hy4 PreviewN/AN/A--
Hy4 PreviewN/AN/A--
Hy4 PreviewN/AN/A--
GLM-5.3N/AN/A--
GLM-5.3N/AN/A--
GLM-5.3N/AN/A--
MiniMax M3N/AN/A--
MiniMax M3N/AN/A--
Qwen3.8-FlashN/AN/A--
Qwen3.8-FlashN/AN/A--
Qwen3.8-FlashN/AN/A--
Qwen3.8 Max (2.4T-A95B)N/AN/A--
Qwen3.8 Max (2.4T-A95B)N/AN/A--
Qwen3.8 Max (2.4T-A95B)N/AN/A--
Muse Glimmer 30BN/AN/A--
Muse Glimmer 30BN/AN/A--
Claude Opus 4.693.7%232.0s19412,123
Claude Opus 4.892.3%73.7s2976,004
Claude Opus 590.8%259.8s29719,349
Claude Haiku 4.590.6%102.9s19313,010
DeepSeek V4 Pro90.4%49.9s1682,938
GPT-5.490.3%64.4s1753,697
Claude Sonnet 4.690.2%269.8s19416,000
Qwen3.5-397B-A17B90.0%55.2s1904,491
Kimi K389.7%389.0s26511,092
Claude Opus 589.6%239.4s29718,381
Claude Opus 589.6%287.0s29721,260
Claude Sonnet 589.6%60.4s2975,591
Qwen3.8 Max (2.4T-A95B)89.1%97.2s22818,809
Qwen3.5-35B-A3B88.8%30.9s1903,884
GLM-5.3-Flash88.8%269.5s18010,497
DeepSeek V4 Pro88.5%212.4s2479,949
GLM-5.388.3%88.8s18010,777
Qwen3.8 Max (2.4T-A95B)88.0%639.7s22824,982
GLM-5.388.0%25.7s1813,110
Kimi K387.8%277.4s2657,957
Claude Sonnet 587.5%75.3s2976,904
GPT-5.6 Sol87.2%107.2s1757,233
Qwen3.8-Flash87.1%239.9s22824,082
DeepSeek V4 Pro86.8%26.3s1692,906
GLM-5.3-Flash86.7%193.8s1807,407
Qwen3.6 27B86.6%68.8s1904,272
GLM-5.286.6%31.0s1802,437
DeepSeek-R186.6%75.7s1682,821
GLM-5.386.5%113.0s18010,354
GLM-5.3-Flash86.5%224.2s1807,788
GPT-5.6 Sol86.4%111.0s1757,707
Mistral Large 3 675B86.4%33.1s1821,828
DeepSeek V4 Flash86.4%25.7s1682,384
Qwen3.6 35B A3B86.1%30.3s1904,210
MiniMax M2.786.1%101.3s1785,913
GPT-5.6 Sol85.8%88.3s1755,939
MiniMax M385.7%36.0s3327,944
Qwen3.5-397B-A17B85.7%62.1s1904,371
Kimi K385.4%369.1s26511,067
GPT-5.6 Terra85.2%96.6s1756,047
Qwen3.8 27B84.7%284.6s22819,079
MiniMax M2.784.7%68.2s1765,139
GPT-5.6 Terra84.5%100.1s1756,604
GPT-5.6 Terra84.5%91.5s1755,990
Qwen3.8-Flash84.3%136.0s22814,935
Qwen3.8-Flash83.7%234.2s22826,048
Claude Sonnet 583.6%42.6s2974,028
Qwen3.5-35B-A3B83.4%24.0s1903,554
DeepSeek V4 Flash83.4%84.8s1682,848
Gemini 3.1 Pro83.1%44.2s1813,430
Mistral Small 260383.1%10.9s1941,806
Qwen3.6 27B82.8%132.1s1904,590
Hy4 Preview82.8%226.5s18917,389
GPT-5.4 nano82.5%14.3s1752,911
MiniMax M2.782.3%169.9s1788,283
MiniMax M382.2%37.2s2804,836
Qwen3.8 27B82.2%98.2s29614,454
MiniMax M382.0%35.8s2804,260
DeepSeek-V3.281.6%79.4s1682,331
MiniMax M2.781.3%82.6s1766,458
DeepSeek V4 Flash81.0%34.7s1682,418
GPT-5.6 Luna81.0%50.9s1755,012
DeepSeek-V3.280.8%159.9s1682,502
DeepSeek-V3.280.8%24.6s1682,321
Qwen3.6 27B80.5%114.9s1903,961
Qwen3.8 27B80.3%170.8s29614,358
Qwen3.5-35B-A3B80.2%32.9s1903,787
DeepSeek V4 Flash80.2%43.6s1682,548
GPT-5.6 Luna80.1%50.2s1754,896
Qwen3.8 Max (2.4T-A95B)79.9%742.4s22831,072
Qwen3.6 35B A3B79.8%15.9s1904,250
Qwen3.5-397B-A17B79.7%41.5s1903,658
Muse Glimmer 30B79.7%33.6s1932,213
Mistral Large 3 675B79.4%25.8s1822,033
Hy4 Preview79.2%238.7s18918,299
Qwen3.6 27B78.5%68.7s1904,284
Qwen3.5-35B-A3B78.5%22.7s1903,693
Mistral Large 3 675B78.3%27.0s1822,204
Hy4 Preview78.3%213.8s18916,014
GLM-5.278.2%67.2s1803,448
Qwen3.6 35B A3B78.1%35.3s1904,733
GLM-5.277.9%70.1s1803,496
GPT-5.4 mini77.5%14.4s1752,423
Mistral Small 260377.0%14.6s1942,017
DeepSeek-V3.276.7%49.1s1682,309
DeepSeek-R176.5%154.8s1693,099
Claude Haiku 4.576.4%106.6s19313,899
Gemma 4 26B A4B IT76.2%16.1s1971,512
Claude Haiku 4.575.8%77.9s1939,313
DeepSeek-V3.275.8%48.7s1682,333
Qwen3.5-397B-A17B75.7%46.8s1904,286
DeepSeek V4 Pro75.2%79.4s1683,383
Mistral Small 260375.0%15.1s1942,183
Gemma 4 26B A4B IT75.0%16.2s1971,472
GPT-5.6 Luna75.0%52.6s1755,143
Mistral Small 260375.0%14.8s1942,037
Claude Haiku 4.574.7%68.4s1938,242
Qwen3.6 35B A3B74.6%22.3s1904,479
Muse Glimmer 30B73.6%33.2s1932,165
Gemma 4 31B IT73.5%41.5s1961,444
Muse Glimmer 30B73.3%34.2s1932,203
Mistral Large 3 675B72.8%24.1s1822,002
DeepSeek-R172.7%143.9s1692,799
GLM-5.271.5%94.8s1803,507
Gemma 4 31B IT71.0%7.2s1961,386
Gemini 3.1 Flash-Lite70.2%6.7s181986
Llama 4 Maverick68.8%33.5s180849
Gemini 3 Flash68.2%9.2s1791,328
Llama 3.3 70B Instruct65.8%28.8s183865
DeepSeek-R165.8%75.8s1671,285
Llama 4 Maverick65.7%37.6s180908
Gemma 4 31B IT65.3%8.3s1961,390
Gemma 4 26B A4B IT64.8%20.3s1961,403
Gemma 4 26B A4B IT63.4%32.6s2121,361
Gemma 4 31B IT62.7%54.8s2121,269
Llama 4 Scout61.8%7.8s180697
Llama 3.3 70B Instruct59.8%24.8s202876
Llama 3.3 70B Instruct58.0%15.7s183830
Llama 4 Maverick56.6%32.5s180722
Llama 4 Maverick56.4%18.2s180854
Llama 4 Scout54.0%17.1s180831
Llama 3.3 70B Instruct52.8%25.5s202809
Llama 4 Scout52.3%16.1s180783
Llama 4 Scout52.3%25.0s180722
DeepSeek-R1-Distill-Qwen-32B50.2%57.8s1761,193

Tags

sopcleaningbioreactor